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Furthermore, propionic acid stimulates enteric neurons to release glutamate, which activates vagal afferents to transmit signals to the CNS, modulating mood-related brain circuits ( Foundation for SCFA production: dietary fiber (especially fructans and galactooligosaccharides) can significantly increase the abundance of Bifidobacterium and Lactobacillus in the gut (124), and these two bacterial groups are the main producers of SCFAs (100102)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Di Filippo M., Chisserini D., Tozzi A., Picconi B., Calabresi P

Common adverse effects include headache and blurred vision, with systemic cholinergic effects such as excessive sweating and increased urination