When the engineered disulfide between Fc A330C and FcRIII I106C forms, the molecule retains bivalent Fab binding to the first target and presents a single FcR fusion for the second
Another possibility is that portal hypertension in cirrhosis may show the characteristics of spleen enlargement in the early stage, and the occurrence of spleen enlargement may be accompanied by hypersplenism, which will further affect the immune function of the body, thus aggravating the development of liver cirrhosis ( Liver cirrhosis and hepatopulmonary syndrome Hepatopulsyndrome (HPS), first proposed by Knudson and Kennedy in 1977 (Weinfurtner and Forde, 2020)
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