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Although most macromolecules in the blood are physically prevented from entering the brain due to the presence of the blood-brain barrier and tight junctions, specific and non-specific transcellular mechanisms transport various macromolecules and complexes across the blood-brain barrier

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One of the most widely recognized extrahepatic manifestations of Wilsons disease is the characteristic KayserFleischer (K-F) ring in the ocular cornea21 (Figure 253)

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