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Acknowledgments Authors want to thank Germaine Pugh and Cassia McClain for their invaluable help in preparing the manuscript, and Jessica Michelle Vasquez-Soltero for processing the gene profiling data

doi:10.21037/tau-20-685

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2** CagriSema resulted in greater weight loss of 22.7% at 68 weeks versus 2.3% in the placebo group when evaluating the treatment effect if all patients stayed on treatment

The dose is increased over time to allow for smooth acclimation and reduced side effects