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doi: 10.3389/fimmu.2021.719023 132 KalraR

Warnings & Precautions For professional use only

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10.1021/acs.jcim.0c00496 2 AmentaF.ParnettiL.GallaiV.WallinA

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Conversely, stressed or dying chondrocytes release DAMPs, apoptotic bodies, cartilage fragments, and pro-inflammatory mediators that further activate synovial macrophages and fibroblasts, maintaining a chronic synovitic state and perpetuating pain and swelling (Li and Sun, 2024)