Tat-induced oxidative stress, DNA damage, and chromosomal aberrations are novel oncogenic factors promoting B-cell lymphomas in HIV-1 infection 123
PMID: 38981469 Dev Cell Setdb1 protects genome integrity in murine muscle stem cells to allow for regenerative myogenesis and inflammation
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phytoactive Se generally exists as selenomethionine, which is biotransformed to synthesize specific selenoproteins and is not directly toxic even at a high doses (109)
However, the directionality, cell specificity, and functional hierarchy among different RNA modifications remain incompletely defined, and future studies are needed to determine which modifications are causal drivers versus secondary stress responses
In a similar concern, therapies targeting EGFR has found resistance to the treatment due to the activation of c-MET signaling axis ( Fig