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Do not use a microwave, hot water, or any heat source to warm the medication, as excessive heat degrades semaglutide and can reduce its effectiveness

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Similarly, IM injections offer an effective alternative, though they are slightly slower than IV therapy in absorption

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With options for higher doses, patients have more flexibility in treatment, which can be tailored to achieve optimal results

Other studies align with these results (133), underscoring the need for further research to elucidate lipid metabolism and pioglitazone treatment