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[1] [6] In addition, the following class-relevant safety considerations apply, based on evidence from related incretin-based agents, and should be regarded as applicable to retatrutide until specific data are available: Gastrointestinal complications: Severe or persistent abdominal pain may indicate pancreatitis and requires urgent medical assessment

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Analyses of the post-reflux swallow-induced peristaltic wave index and nocturnal baseline impedance parameters increase the diagnostic yield of impedance-pH monitoring of patients with reflux disease

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Serious adverse events are rare but can include pancreatitis or gallbladder issues

10.1073/pnas.95.4.1852 125