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Elsevier BV: 13261332

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For instance, secreted virulence factors regulate the expression of downstream target proteins, activate NF-B, ERK/MAPK, JAK/STAT, and other signaling pathways or cytokine receptors, enhance or inhibit the inflammatory response after infection, and promote the proliferation and metastasis of GC

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The mucus layer of the gut is the scenario where most of the host-microbiota interactions take place