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This review uniquely integrates the gastrointestinal and tumor microenvironment barriers encountered in oral chemotherapy for CRC and establishes the rationale for using nanoparticle-based drug delivery and for developing suitable nanoformulations to overcome these barriers and impart therapeutic effects

Gastrointestinal adverse reactions with levocarnitine oral solution dissolved in liquids might be avoided by a slow consumption of the solution or by a greater dilution

Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating

Endoplasmic reticulum stress is a state in which the accumulation of unfolded/misfolded proteins is accelerated after ER disorders caused by a variety of physiological and pathological conditions

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