Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)
"Long-term drug treatment for obesity: a systematic and clinical review"
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These effects typically resolve within the first week or two of use
Healthy tissues don't express the complete receptor
Dosing and cycling decisions should reflect individual goals, health history, medications, and risk factors