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Possibilities include: fecal SCFA levels (as an indicator of beneficial fermentation), serum TMAO (marker of detrimental microbial metabolism), gut permeability assays (like urinary sugar tests or blood zonulin) to gauge gut barrier integrity, and even gut microbial gene profiles that might predict rapid vs slow disease progression

Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit

Weight reduction should be gradual (0.51 kg weekly) to avoid rapid mobilisation of fat, which paradoxically may worsen liver inflammation

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PLoS ONE 8 (12), e82459 (2013)

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