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Nevertheless, the paired study design was adequately powered to determine clinically relevant changes in GPR and gluconeogenesis and the sample size was comparable with those of other stable isotope studies examining metformins in vivo glucose-lowering effects [8, 10,11,12,13]

Brown or blue pigmented lesions may be caused by overproduction of melanin in basilar melanosis or in benign nevi and malignant melanomas, which are associated with melanocyte overpopulation

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