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Individuals with type 2 diabetes typically experience an impaired incretin effect, though GLP-1 secretion itself may be normal, slightly reduced, or context-dependent

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Biotechnol Bioeng 74(6):492497

421 Notably, dotinurad has demonstrated safety in patients with an estimated glomerular filtration rate (eGFR) between 60 ml/min and 30 ml/min, without necessitating any dosage adjustments

Yale Medicine: What Is the Impact of GLP-1s in Older Adults with Obesity