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Although various PHGDH inhibitors have been developed (including ketothioamide, BI-4924, indoleamide, piperazine-1-thiourea inhibitors, and allosteric inhibitors) and have demonstrated anti-tumor effects, no PHGDH inhibitors have been approved by the FDA for clinical application, as a result of challenges such as metabolic compensation, drug selectivity, resistance, toxicity, and the complexity of drug development [165, 166]

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L-glutamine: This is needed to make other amino acids, and is essentially a fuel for the cells of the immune system

10.3389/fphar.2021.630210 56 ZhouS.AiZ.LiW.YouP.WuC.LiL.et al (2020)

G values were computed by comparing the energy of the wild-type protein to that of the mutant in its most stable conformation