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13 Journal of Medicinal Chemistry (ACS)Bisubstrate inhibitors of NNMT with enhanced activity

Contraindications/Precautions Cyanocobalamin is contraindicated in those with hypersensitivity to cobalt moiety or cobalamin molecule due to the risk of anaphylaxis (9)

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In controlled research environments, 5-AMINO-1MQ has been examined as a tool compound to support investigation into: NNMT-related metabolic pathways Cellular methylation processes involving nicotinamide metabolism Regulation of metabolic flux and energy balance in preclinical models Molecular mechanisms associated with metabolic signalling and cellular homeostasis Research involving 5-AMINO-1MQ is conducted using in vitro and preclinical experimental models to better understand NNMT-mediated biochemical processes and downstream cellular responses