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The hormone can also reduce COX-2 synthesis directly by blocking the transcription of the COX-2 activator (p52) by inhibiting the activity of p300 histone acetyltransferase (HAT) [33,48]

Key compounds such as withaferin A, withanolide A, and withanosides have demonstrated antioxidant, anti-inflammatory, neuroprotective, immunomodulatory, and anticancer activities

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Interestingly, a protective role of Se occurs in organs that are the typical body sites of human cancers (i.e., stomach, intestine, mammary glands, and liver) [47]

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Alcohol disrupts the effect of anaesthesia on the body