At present, there is no definitive evidence of the interaction between the circadian clock system and the GH/IGF-1 axis and the pathophysiological mechanism causing metabolic disorders
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Hypoglycemia IGF-1 mimics insulin and promotes glucose uptake, which can lead to low blood sugar , especially when fasted or combined with insulin or GH
They received once-weekly subcutaneous injections of either 5 mg, 10 mg, or 15 mg of tirzepatide or a placebo over a period of 40 weeks
Dimitriadis GD, Raptis SA