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A 2022 meta-analysis of 37 RCTs involving 3,048 patients, published in Frontiers in Pharmacology , found that berberine significantly reduced fasting plasma glucose by an average of 0.82 mmol/L and HbA1c by 0.63% without significantly increasing hypoglycemia risk

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These findings challenge the commonly held assumption that neuroinflammation necessarily leads to BBB breakdown

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