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Introduction Chronic obstructive pulmonary disease (COPD) is a chronic airway disorder manifested by a persistent airflow obstruction and pulmonary parenchymal destruction, characterized by chronic airway inflammation and emphysema and finally causing respiratory failure ( Glycyl-L-histidyl-L-lysine (GHK) is a natural component of human plasma ( 2+ (GHK-Cu) by the good affinity for Cu(II), which proved to exhibit good antioxidant and anti-inflammatory capabilities ( We have reported on the anti-inflammation and anti-fibrosis effects of the tripeptide, GHK, in pulmonary fibrosis ( Methods Experimental protocols Sixty C57BL/6J male mice (1820 g, 810 weeks, Changsheng Biotechnology Company, Liaoning, China) were housed and fed at the First Hospital of China Medical University, the Institute of Respiratory Disease, under quiet and controlled specific pathogen-free conditions

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PMID: 25038357