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Interestingly, single alanine amino acid substitutions of some interacting residues within the TMD had much larger effects on exendin-4 affinity than removal of the first 8 residues of the peptide (exendin (939) 22,31 ), suggesting that peptide ECD and TMD interactions are correlated

Unlike GLS1, GLS2 is not inhibited by CB-839 or glutamate (its immediate byproduct), and can directly bind and inhibit Rac1 (Ras-related C3 botulinum toxin substrate 1), suppressing murine and human hepatocellular carcinoma cells migration and metastasis in a mouse model [205]

International Journal of Molecular Sciences , 25 (7), 3745

Wessells H, Levine N, Hadley ME, et al

Extrapolating that result wholesale to GHK-Cu is a reasonable hypothesis, not an established fact

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