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Conclusions/interpretation In well-controlled metformin-treated type 2 diabetes, glucose-lowering by metformin is greater when it is given before, rather than with, enteral glucose, and this is associated with a greater GLP-1 response

Therapeutic targeting of the IGF axis

Contraindications include known hypersensitivity to mannitol (present in the formulation), active malignancy, pregnancy, disruption of the hypothalamic-pituitary axis (after surgery, radiation or major trauma), and severe hypersensitivity to any component of the lyophilized product

A., Tatalovic, M

Clinical trials demonstrate that liraglutide reduces liver fat, improves liver function, and decreases inflammatory markers, though its effects on epicardial adipose tissue (EAT) are inconsistent