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Tirzepatide is a first-in-class and only GLP-1/GIP dual agonist

Reduced FTH1 levels in cells cause iron metabolism abnormalities and ROS accumulation, thereby inducing ferroptosis

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Patients should be counseled that traditional weight loss approaches will not eliminate lipedema fat but can improve overall metabolic health

909 Poliumoside, extracted from Callicarpa kwangtungensis Chun , inhibits bone degradation and ferroptosis induced by a high-glucose and high-fat diet through the Nrf2/GPX4 pathway, increases femoral bone mineral density, and prevents osteoporosis associated with type 2 diabetes

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