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Animal models suggest that DPP4 inhibitors increase circulating concentrations of the myokine irisin as well as peroxisome proliferator-activated receptor coactivator-1-alpha [146], a key component of the muscle response to exercise

RC reports consulting and lecture fees from Astellas, Akern, Baxter, B-Braun, Bristol-Myers Squibb, Boehringer Ingelheim, Eli Lilly, Fresenius Kabi, Lionhealth, Nestl Health Science, Novartis, Nutrisens, MSD, Nutricia, Pfizer, Roche, Servier, Takeda, Viatris, all outside the submitted work

He describes his experience as "the dial moved in the right direction" rather than anything more dramatic

Originally FDA-approved as Ozempic for type 2 diabetes in 2017, semaglutide was subsequently approved as Wegovy for chronic weight management in 2021 making it one of the most rigorously studied weight loss medications ever approved

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This definitional vagueness poses significant challenges to the development of objective and reproducible criteria for evaluating efficacy