who discovered glp 1 agonists How GLP-1 Receptor Evolved from Diabetes to Weight Loss Treatments Discovery of GLP-1–Based Drugs for

5.1 Long-term effects due to prolonged usage of probiotics 5.1.1 Disruption of gut microbiota balance Prolonged probiotic use may interfere with the natural recovery of gut microbiota, particularly following antibiotic treatment

doi: 10.1056/NEJMoa1800256 57 RodriguezR.EscobedoB.LeeA

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Front Neurol (2020) 11:828

[DOI] [PubMed] [Google Scholar] 20.Duguay SJ, Milewski WM, Young BD, Nakayama K, Steiner DF

GLP-1R agonism also promotes -cell growth and survival by stimulating the expression of the insulin receptor substrate 2 (Irs2) via mechanisms that include activation of CREB [546]