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In humans, GABA concentrations or GABA-receptor densities have been found to be reduced in epileptic patients [100,101], and reduced binding to benzodiazepines has been demonstrated in the mesial temporal lobe on positron emission tomographic scanning [102,103] meaning reduced inhibitory capacity and responsiveness to pharmacological activation

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Glutamine-driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

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Lastly, integrated modelling frameworks that account for biophysical, agronomic, and socio-economic factors are essential for projecting the implications of eCO 2 on food security, farm productivity, and global food systems (Campbell-Lendrum et al