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Some studies have indicated that people suffering from depression respond better to medication when they have healthy levels of vitamin B12 in their systems

This points to the value of combined treatments

In one study comparing zinc pyrithione to a strong steroid cream (betamethasone) and a non-steroid prescription cream (tacrolimus), all three treatments improved symptoms after four weeks

Yazici KU, Percinel I

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A prospective randomized controlled trial of Q-switched Nd:YAG laser with topical 3% tranexamic acid (TA) versus microneedling with topical 3% tranexamic acid (TA) in treatment of melasma