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A recent trial examining the effect of the SGLT-2i ipragliflozin in Japanese people with obesity revealed similar mean reductions of fat mass and total lean mass of 1.8 kg and 1.7 kg, respectively, including a small but significant 0.6 kg loss in appendicular lean mass (a good marker of skeletal muscle mass), suggesting that SGLT-2is may induce catabolism of both body fat and muscle secondary to glycosuria [36]

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There were reports of MTC in the landmark trials with GLP-1 RAs such as Victoza

However, this doesnt mean that the studies establish a direct cause-and-effect relationship

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