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Reaching the sufficient range (20 ng/mL or 50 nmol/L) is the threshold used in the PCOS-fertility meta-analysis above, 4 though some endocrine guidelines target 30 ng/mL (75 nmol/L) for general health

Together, these results reinforce the concept that AKT1 acts as a key integrator of metabolic stress and transcriptional reprogramming in lipedema, orchestrating alterations in energy production, amino acid metabolism, and antioxidant defence

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These can lead to a condition called oxidative stress

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