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doi: 10.1038/ctg.2013.9 224 WangWJovelJHalloranBWineEPattersonJFordGet al

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5-amino-1MQ did not inhibit SIRT1 concentrations ranging from 10 nM 300 M, and minor reduction in SIRT1 activity was observed with 600 M 5-amino-1MQ (Figure 4E)

Researchers have recently observed a significant protective effect against KA-induced excitotoxicity and hippocampal superoxide production in vivo in Tau gene knockout mice [144]