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This faster escalation means peak effectiveness may arrive sooner with retatrutide, though the GI side effects during escalation tend to be more pronounced

it also has a high prevalence of obesity and type two diabetes

As a consequence, there is a massive secretion of water, provoking severe diarrhea (14)

The AMPLITUDE-O trial, which studied Efpeglenatide versus placebo with a mean follow-up of 1.81 years, demonstrated a significant 27% reduction in MACE

When areas of the body are subject to ongoing inflammation, many issues can arise

GI side effects during escalation vs maintenance Both compounds share an important characteristic: most gastrointestinal side effects occur during dose escalation, not during maintenance