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Kaempferol activates the Nrf2/SLC7A11/GPX4 pathway, boosting antioxidant defenses and reducing neuronal ferroptosis in OGD/R-induced damage, showing promise for CIRI treatment, though further animal studies are needed (Yuan et al., 2021)

Compounding decisions are made by a licensed prescriber and a licensed pharmacy under current federal and state law

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The Pharmacy Compounding Advisory Committee reviews scientific evidence, safety information and clinical need before making recommendations to the FDA regarding whether a substance should be included on that list