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Based on similarities in their amino acid sequence, GLP-1RAs are peptide derivatives of either exendin-4 (exenatide, lixisenatide, and efpeglenatide) or human GLP-1 (albiglutide, dulaglutide, liraglutide, and semaglutide)

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Pfizer's withdrawal from the oral GLP-1 space leaves orforglipron without a near-term small-molecule competitor

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