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This dysfunction may be caused by the inhibition of multiple enzymes and/or transporter proteins involved in fatty acid -oxidation metabolism by VPA ( Studies on the inhibitory effect of VPA on mitochondrial fatty acid -oxidation have shown that VPA has different inhibitory effects on fatty acid oxidation of different chain lengths

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Orally administered glutathione is only sparingly absorbed due to its rapid hydrolysis by -glutamyltransferase present in intestinal mucosa, hepatocytes and cholangiocytes

Interestingly, DMF was found to induce cysteine biosynthesis 26 , elevate cellular GSH levels 27 , and present an NRF2-independent effect through posttranslational protein succinylation 28,29

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