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Similar microbial signatures have been observed in AD and MS, suggesting a shared microbiome-inflammation axis that contributes to disease pathophysiology [618, 619]
Using this criterion, we found that MIF (encoding macrophage migration inhibitory factor, 1.4 logfold increase in -1), SERPINA1 (encoding -1-antitrypsin, 0.8 logfold increase in -1, 0.4 logfold increase in -2), REG1A (encoding lithostathine-1-, 0.6 logfold increase in -2), and GLS (encoding glutaminase, 0.7 logfold increase in -2) are the genes encoding a secreted protein with the greatest increase in cells in response to liraglutide treatment (Supplemental Table 2)
Venn diagrams were computed with the package ggvenn [41] and exported using the package gplots [42] in R
Jeffrey Egler, MD, is a double board-certified physician in Family Medicine and Lifestyle Medicine
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