In both cases, 0.1 M SFN maintained cellular ROS close to control levels (SFN 1.121 0.2981 and VPA + SFN 1.421 0.1935-fold change from control), attenuating VPA-induced ROS production (VPA + SFN vs VPA p = 0.0918
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One hypothesis is that naltrexone may indirectly reduce ketamine-induced glutamate release by inhibiting MOR activation on GABAergic interneurons
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doi: 10.1055/s-0035-1548790 143 JamilianMRazaviMFakhrie KashanZGhandiYBagherianTAsemiZ