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MT-2 acts centrally, binding hypothalamic MC4R receptors and directly altering hunger signaling before food is consumed

58 Food polyphenols can also induce apoptosis in cancer cells such as breast carcinoma cell line (MCF-7), human laryngeal epithelioma cell line (HEp2), human cervical cancer cell line (HeLa), human hepatoma cell line (HepG2), human hepato-cellular liver carcinoma cell line (HepG2), acute myeloid leukemia cell line (AML)

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Such limitations prompted the development of second-generation medicines capable of sustaining stable drug concentrations with reduced dose frequency, hence enhancing both effectiveness and tolerance characteristics

doi: 10.1038/s41419-022-05384-6 83 OuYWangSJLiDChuBGuW

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