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This approach balances therapeutic benefits against theoretical concerns about long-term continuous use, for which we lack human safety data

Computed geometries and energies can be accessed through the Zenodo repository ( Source data are provided with this paper

The many types of intranasal nanoparticles being developed (polymeric, solid lipid, microemulsions and nanoemulsions, polymeric micelles, nanonstructured lipid carriers, polymer-lipid hybrid, chitosan and PGLA nanoparticles) speak to the richness of this drug delivery field

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Thigh injections are spaced every 3 to 4 weeks

Studies among both AD dementia populations as well as in preclinical asymptomatic AD coupled with biomarker testing, are needed to address remaining gaps to translation