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Dulaglutide is a fusion protein consisting of two identical disulfide-linked chains, each composed of a GLP-1 analog (90% homology with native GLP-1) covalently linked to a modified human IgG4 Fc domain [25]

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Overall, we found that CAR T cells in post-infusion BM samples from LTR have high levels of mTOR signaling, high metabolic polyfunctionality, and an effector immunometabolic profile, and that the BM microenvironmental milieu of LTR may promote mTOR activity for improved anti-tumor activity