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Intraperitoneal GLP-1 was shown to lower plasma glucose in GLP-1R knockdown mice without increasing insulin secretion, whereas intravenous GLP-1 did not affect glucose or insulin levels

Higher doses produce more total weight loss, but the proportion of that weight loss coming from fat versus lean tissue varies with dose, activity level, and protein intake during the protocol

Symptoms can include abdominal pain, diarrhea, and weight loss

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Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

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