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alternatively, the dose of drug being administered are temporarily reduced or temporarily suspended for a certain length of time (i.e., a drug holiday)

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22 In addition, AARS1 senses intracellular lactate and serves as a bona fide lactyltransferase that directly uses lactate and ATP to catalyze the lactylation of Yes-associated protein (YAP) at K90 and the transcriptional enhanced associate domain (TEAD) at K108

The problem with all these studies, though, is they were all on people who started out mentally healthy

TRIUMPH Phase 3 Retatrutide Trials (NCT05929014 and related)