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JAMA 2014;312:380-389

Remarkably, immune checkpoint inhibitor (ICI) treatment targeting the PD-1/PD-L1 pathway is highly effective for metastatic mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) CRC 6

In rare cases, there may be: arrhythmia

Recent research has highlighted the potential for microbiome-based therapeutic strategies, such as probiotics, prebiotics, fecal microbiota transplantation (FMT), and dietary modifications, to restore microbial balance and alleviate disease symptoms

clinical study, 77% of TOPS patients achieved overall clinical success compared to 24% of fusion patients

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