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To determine whether the pharmacotherapy-induced reduction in muscle mass is maladaptive (i.e., impairs muscle function) or adaptive to lower body weight with minimal functional consequence, objective functional testing is required to assess muscle strength and physical functional performance

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Xu X, Li N, Wen J, Yang P, Lu X, Wang Z, et al

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5 and 6) can pass through epithelial cell layers with a transcellular absorption mechanism with the help of permeation enhancers like salcaprozate sodium (SNAC, see Fig