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2021 2 Impact reports key developments to the full Board

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The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity

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The summary of fungal changes in ALD, MASLD, PSC, liver cirrhosis, and HCC compared with healthy individuals is presented in Table 6