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NPJ Parkinsons Dis 2020;6:4

ClemmensenCChabenneJFinanBSullivanLFischerKKuchlerDet al

Given that GSH is the predominant ROS-scavenger in cells, and the source of reducing equivalents for many redox modulating enzymes such as peroxidases, peroxiredoxins and thiol reductases 7 , the loss of GSH significantly impairs cellular response to oxidative stress

The described methodologies are broadly applicable and adaptable to Fabry disease involving diverse tissues, including the heart, brain, and skin, and can be used immediately to experimentally investigate molecular pathways and novel treatments

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