Caspase-3 activity in HepG2 cells treated with aspirin and after manipulation of GSH levels by BSO and NAC was measured using DEVD peptide conjugated to p-nitroanaline as described in the vendor's protocol (Figures 8A, B)
What we do NOT know The gaps here are large enough that unknown long-term safety should itself be treated as a risk, not a green light: No long-term human safety data
The European Food Safety Authority (EFSA) established a no-observed-adverse-effect level (NOAEL) of 800 mg/kg body weight per day based on rat studies
Leonel C, Gelaleti GB, Jardim BV, Moschetta MG, Regiani VR, Oliveira JG, et al
Cerebral microvascular pathology in aging and Alzheimers disease
Its half-life is generally considered relatively short, often around a few hours or less