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Through its metabolites, such as AFMK and 6-OHM, melatonin enhances GSH levels, a key antioxidant, and mitigates UVB-induced GSH depletion 198

B vitamins, especially the methylated vitamins B6, B9, and B12, are also critical to help the body produce glutathione, as is magnesium

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SLCs has become a prominent strategy for brain drug delivery of nanoparticles by functionalization with ligands such as hexoses, amino acids or vitamins [18]

The underlying mechanisms are complex, involving direct and indirect toxic effects, immunologic dysregulation, and oncogenic pathways, primarily driven by oxidative stress, systemic inflammation, insulin resistance, and the presence of numerous carcinogens in tobacco smoke