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Starting Dose: Typically administered once daily at the same time each day

In the early stage, inflammation leads to the secretion of inflammatory and pro-degradative mediators, including cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor- (TNF-), lipid mediators such as prostaglandin E2 (PGE 2 ), and matrix metalloproteinases (MMPs) by macrophages and fibroblast-like synoviocytes 7,10

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Consequently, this review aimed to synthesize the latest findings from both animal and clinical studies, while also examining the potential for comprehensive treatment approaches for tinnitus using TCM based on the understanding of its pathophysiology and neuroimaging mechanisms

Perspective: 12% of participants continued losing weight through week 48 without plateau

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