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Evidence Supporting this KER Overall Weight of Evidence: Moderate Biological Plausibility The biological plausibility of the relationship between increased oxidative stress leading to increased DNA double strand breaks (DSBs) is highly supported by the literature

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Fructose-2,6-bisphosphate is a powerful allosteric activator of phosphofructokinase-1, which phosphorylates fructose-6-phosphate to fructose-1,6-bisphosphate, allowing glycolysis to proceed (Fig

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