Preclinical studies and emerging clinical data indicate that this effect may be dose-dependent, meaning therapeutic benefit can be achieved without the side effects typically associated with higher doses used in metabolic treatment
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Calcitonin binds to calcitonin receptors on osteoclasts, directly inhibiting their bone-resorbing activity
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In research terms, these findings support the use of cagrilintide in models that examine how amylin signaling may affect not only body weight and glucose control, but also the larger network of metabolic pathways tied to cardiometabolic status
Wiese, Jeff, et al
